Recently I had cause to configure iSCSI multipathing on a test ESXi server. The production environment servers use iSCSI HBAs to connect to the back end storage, so multipathing them is a straight-forward setup.
It’s good practice to separate VMotion, virtual machine and iSCSI traffic, it also helps you manage those logical and physical connections.
Connect to your ESXi server using the vSphere Client and select the host. Go to the configuration tab and click “Add Networking…”.